Growth Differentiation Factor 5 (GDF5) (Middle Region) Peptid
GDF5
Reaktivität: Human
Wirt: Synthetic
BP, WB
Produktnummer ABIN5510991
Kurzübersicht für Growth Differentiation Factor 5 (GDF5) (Middle Region) Peptid (ABIN5510991)
Target
GDF5
(Growth Differentiation Factor 5 (GDF5))
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequenz
- DEPKKLPPRP GGPEPKPGHP PQTRQATART VTPKGQLPGG KAPPKAGSVP
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Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- GDF5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GDF5 (Growth Differentiation Factor 5 (GDF5))
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Hintergrund
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The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. These associations confirm that this gene product plays a role in skeletal development. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Alias Symbols: OS5, LAP4, BDA1C, BMP14, CDMP1, LAP-4, SYM1B, SYNS2, BMP-14
Protein Size: 501 -
Gen-ID
- 8200
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NCBI Accession
- NM_000557, NP_000548
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UniProt
- P43026
Target
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